Human Angiotensin Converting Enzyme 2, ACE2 ELISA Kit

Full product name

Angiotensin Converting Enzyme 2

Code

E3169Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

0.021ng/ml

Detection range

0.05-20ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed: 27217402). Converts angiotensin I to angiotensin 1-9, a nine-amino acid Peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed: 10969042, PubMed: 10924499, PubMed: 11815627, PubMed: 19021774, PubMed: 14504186). Also removes the C-terminal residue from three other vasoactive Peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed: 10969042, PubMed: 11815627). Also cleaves other biological Peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin-7, neocasomorphin) and dynorphin A with high efficiency (PubMed: 11815627, PubMed: 27217402, PubMed: 28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed: 18424768, PubMed: 19185582). [Isoform 2]: Non-functional as a carboxypeptidase. (Microbial infection) Acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. [Isoform 2]: (Microbial infection) Non-functional as a receptor for human coronavirus SARS-CoV-2.

UniProt accession

Q9BYF1

MASS?Da?

92,463

GeneID

59272

Synonyms

ACE 2;ACE2;ACEH;ACE-related carboxypeptidase;Angiotensin-converting enzyme 2;Angiotensin-converting enzyme homolog;Angiotensin-converting enzyme-related carboxypeptidase;Metalloprotease MPROT15;Processed angiotensin-converting enzyme 2;

Gene names

ACE2

Research area

Microbiology; Cell Biology; Cardiovascular

Target protein

ACE2

https://pubmed.ncbi.nlm.nih.gov/34384355/