Human Hepcidin, HEPC ELISA Kit

Full product name

Hepcidin

Code

E1019Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

5.12pg/ml

Detection range

10-4000pg/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed: 22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed: 11113131, PubMed: 11034317).

UniProt accession

P81172

MASS?Da?

9,408

GeneID

57817

Synonyms

HEPC;Hepc20;Hepc25;Hepcidin;Hepcidin-20;Hepcidin-25;LEAP-1;Liver-expressed antimicrobial Peptide 1;PLTR;Putative liver tumor regressor

Gene names

HEPC

Research area

Cardiovascular

Target protein

HEPC

https://pubmed.ncbi.nlm.nih.gov/28276006/

https://pubmed.ncbi.nlm.nih.gov/33554466/