Human Insulin-like Growth Factors 1, IGF-1 ELISA Kit

Full product name

Insulin-like Growth Factors 1

Code

E0103Hu

Assay type

Sandwich

Size

96T,48T

Sensitivity

0.058ng/ml

Detection range

0.1-40ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

The Insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed: 21076856, PubMed: 24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed: 19578119, PubMed: 22351760, PubMed: 23696648, PubMed: 23243309).

UniProt accession

P05019

MASS?Da?

21,841

GeneID

3479

Synonyms

IGF 1;IGF1;IGF-I;Insulin-like growth factor I;Mechano growth factor;MGF;Somatomedin-C

Gene names

IGF1

Research area

Signal Transduction; Cancer; Developmental Biology

Target protein

IGF1