Human Visfatin, VISFATIN ELISA Kit

Full product name

Visfatin

Code

E0025Hu

Assay type

Sandwich

Size

96T,48T

Sensitivity

0.23ng/ml

Detection range

0.5-100ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

UniProt accession

P43490

MASS?Da?

55,521

GeneID

10135

Synonyms

NAmPRTase;Nampt;Nicotinamide phosphoribosyltransferase;Pre-B cell-enhancing factor;Pre-B-cell colony-enhancing factor 1;VISFATIN

Gene names

VISFATIN

Research area

Metabolism

Target protein

VISFATIN

https://pubmed.ncbi.nlm.nih.gov/24228809/

https://pubmed.ncbi.nlm.nih.gov/26023633/

https://pubmed.ncbi.nlm.nih.gov/33247685/