Rat Caspase 3, CASP3 ELISA Kit

Full product name

Caspase 3

Code

E1648Ra

Assay type

Sandwich

Size

48T,96T

Sensitivity

0.02ng/ml

Detection range

0.05-10ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Rat

Storage

2-8ºC

Assay time

1h 30m

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress.

UniProt accession

P55213

MASS?Da?

31,492

GeneID

25402

Synonyms

Apopain;CASP 3;CASP3;CASP-3;Caspase-3;Caspase-3 subunit p12;Caspase-3 subunit p17;CPP-32;Cysteine protease CPP32;IRP;LICE;Protein Yama;SCA-1;SREBP cleavage activity 1

Gene names

CASP3

Research area

Cell Biology; Cancer; Metabolism

Target protein

CASP3

https://pubmed.ncbi.nlm.nih.gov/30426792/